Hyperbaric Oxygen Therapy Research Library
Clinical Evidence & HBOT Studies for Hyperbaric Oxygen Therapy
The Hyperbaric Oxygen Therapy Research Library is designed to provide physicians, clinicians, healthcare leaders, and hyperbaric professionals with access to educational resources, clinical literature, white papers, and evidence-based materials related to Hyperbaric Oxygen Therapy (HBOT).
This library includes research and educational content focused on:
- Hyperbaric medicine and physiology
- Wound healing and limb salvage
- Radiation tissue injury
- Infection management
- Clinical outcomes and evidence summaries
- Program development and operational guidance
As hyperbaric medicine continues to evolve, access to trusted clinical information remains essential for supporting informed decision-making, patient care, and responsible program growth.
The resources within this section are intended to support ongoing education and awareness across the hyperbaric medicine community and will continue to expand over time through new publications, research updates, and clinical insights.
Explore Research and Educational Resources
Browse available white papers, clinical publications, educational materials, and evidence summaries related to Hyperbaric Oxygen Therapy and advanced wound care.
- Outcomes of Radiation Injuries Using Hyperbaric Oxygen Therapy: An Observational Cohort Study
- Comparing near infrared spectroscopy and transcutaneous oxygen measurement in hard-to-heal wounds: a pilot study
- Guidelines for the use of topical oxygen therapy in the treatment of hard to heal wounds based on a delphi consensus.
- Hyperbaric oxygen therapy in preventing mechanical ventilation in COVID-19 patients: a retrospective case series
- Molecular Biomarkers of Oxygen Therapy in Patients with Diabetic Foot Ulcers
- Outcomes of Radiation Injuries Using Hyperbaric Oxygen Therapy: An Observational Cohort Study
- Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial
- A Clinical Trial Design for Evaluating Topical Antimicrobials in Chronic Wounds: The BLEU Trial
- Are Semi-Quantitative Clinical Cultures Inadequate? Comparison to Quantitative Analysis of 1053 Bacterial Isolates from 350 Wounds
- Novel Multivalent Wound-Healing Ointment Provides Bioburden Control and Moisture Management: A Retrospective Registry Data Analysis
- The use of a point of care test for Bacterial Protease Activity
- Uncovering the high prevalence of bacterial burden in surgical site wounds with point-of-care fluorescence imaging
- Cellular, acellular, and matrix-like products (CAMPs) for soft-tissue reconstruction in acute surgical and traumatic wounds
- Suggested minimal evidence for CAMP coverage
- Evaluation of human placental-based cellular, acellular and matrix-like products (CAMPs) in the management of nonhealing diabetic foot ulcers
- Evaluating several cellular, acellular, and matrix-like products (CAMPs) and standard of care in the management of non-healing pressure ulcers using matched controls
- A multicenter, prospective randomized controlled modified dual platform trial evaluating several CAMPs and standard of care vs. standard of care alone in the management of nonhealing diabetic foot ulcers and venous leg ulcers
- Evaluation of cellular, acellular, and matrix-like products in the management of nonhealing venous leg ulcers
- Evaluation of multiple cellular, acellular, and matrix-like products (CAMPs) and standard of care vs. standard of care alone in the treatment of nonhealing diabetic foot ulcers
- Evaluation of cellular, acellular, and matrix-like products (CAMPs) in the management of nonhealing diabetic foot ulcers
- Evaluation of cellular, acellular, and matrix-like products (CAMPs) in the management of nonhealing diabetic foot ulcers
- Evaluation of cellular, acellular, and matrix-like products in the management of nonhealing venous leg ulcers
- A Diagnostic-Driven Prospective Clinical Study Evaluating the Combination of an Antibiofilm Agent and Negative Pressure Wound Therapy
- A double-blind trial comparing an antimicrobial combination to standard care in hard-to-heal wounds
- Evaluation of the combination of a biofilm-disrupting agent and negative pressure wound therapy: a case series
- Preventing, minimizing, and managing pain in patients with chronic wounds: challenges and solutions
- Reliance on Clinical Signs and Symptoms Assessment Leads to Misuse of Antimicrobials: Post hoc Analysis of 350 Chronic Wounds
- Skin Pigmentation Impacts the Clinical Diagnosis of Wound Infection: Imaging of Bacterial Burden to Overcome Diagnostic Limitations
- Evaluation of intact fish skin grafts plus standard care in the treatment of venous leg ulcers: an abstract
- Evaluation of intact fish skin grafts plus standard of care in the treatment of venous leg ulcers: research article
- A Global Perspective on Wound Care
- A New Term: The Point of Pathogenicity
- Consensus principles for wound care research obtained using a Delphi process
- Defining a New Diagnostic Assessment Parameter for Wound Care: Elevated Protease Activity (EPA), an Indicator of Non-healing, for Targeted Protease-modulating Treatment
- Determining Which Cellular and/or Tissue-base Product to Use
- Enhancing Patient Centricity and Advancing Innovation in Clinical Research with Virtual Randomized ClinicalTrials (vRCTs)
- The Early Identification and Prevention of Surgical Wound Complications
- Novel Strategies to Prevent Surgical Site Infections
- Optics are the Astronomy of Wound Healing
- Optimizing Prevention of Surgical Wound Complications: Detection, Diagnosis, Surveillance and Prediction
- Percentage area reduction at week 4 as a prognostic indicator of complete healing in patients treated with standard of care: a post hoc analysis
- Principles of Best Diagnostic Practice in Tissue Repair and Wound Healing: An Expert Consensus
- Proceedings of the Leaders in Wound Healing Conference: 2021
- Proceedings of the Leaders in Wound Healing Conference: 2023
- Proposal for a New Pressure Ulcer (Pressure Injury) Classification Based on Depth, Infection and Perfusion
- SensiLase Studycast System: A Platform for Critical Limb Diagnostics and Electronic Referral Program
- Skin Substitutes for the Treatment of Hard-to-Heal Wounds
- Use of Topical Oxygen Therapy in Wound Healing
- Wound care certification: The grin without a cat
- Standardised Reporting Outcomes for trials investigating Surgical WOund Complications (ROSWOC) Protocol for the development of a core outcomes set
- Changes in the extracellular matrix surrounding human chronic wounds revealed by 2-photon imaging
- Diagnostic Accuracy of Point-of-Care Fluorescence Imaging for the Detection of Bacterial Burden in Wounds: Results from the 350-Patient Fluorescence Imaging Assessment and Guidance Trial
- Fluorescence Image Guided Use of an Antibiofilm Agent in the Treatment of Recalcitrant Pilonidal Ulcers: A Case Review
- Guidelines for Point-of-Care Fluorescence Imaging for Detection of Wound Bacterial Burden Based on Delphi Consensus
- Incorporating Point-of-Care Bacterial Fluorescence into a Wound Clinic Antimicrobial Stewardship Program
- Point-of-care fluorescence imaging reveals extent of bacterial load in diabetic foot ulcers
- Point-of-care fluorescence imaging to optimise wound bed preparation prior to cellular and/or tissue-based product(CTP) application
- Real-time bacterial fluorescence imaging accurately identifies wounds with moderate-to-heavy bacterial burden
- Use of fluorescence imaging to optimize location of tissue sampling in hard-to-heal wounds
- Flourescence Imaging in Surgical Wound Management - A consensus-based approach
- A multicenter, randomized, controlled clinical trial evaluating the use of dehydrated human amnion/chorion membrane allografts and multilayer compression therapy vs. multilayer compression therapy alone in the treatment of venous leg ulcers
- A Multicenter, Randomized, Controlled, Clinical Trial Evaluating Dehydrated Human Amniotic Membrane in the Treatment of Venous Leg Ulcers
- A multicentre, prospective, randomized controlled modified platform trial evaluating PURION processed lyophilized human amnion/ chorion membrane and standard of care versus standard of care alone in the treatment of non-healing diabetic foot ulcers
- A prospective, randomised comparative study of weekly versus biweekly application of dehydrated human amnion/chorion membrane allograft in the management of diabetic foot ulcers
- A prospective, randomised, controlled, multi-centre comparative effectiveness study of healing using dehydrated human amnion/chorion membrane allograft, bioengineered skin substitute or standard of care for treatment of chronic lower extremity diabetic ulcers
- A prospective, randomized, controlled, crossover study comparing three multilayered foam dressings for the management of chronic wounds
- A prospective, randomised, controlled, multicentre clinical trial examining healing rates, safety and cost to closure of an acellular reticular allogenic human dermis versus standard of care in the treatment of chronic diabetic foot ulcers
- A randomized controlled clinical trial of a hypothermically stored amniotic membrane for use in diabetic foot ulcers
- Aseptically Processed Placental Membrane Improves Healing of Diabetic Foot Ulcerations: Prospective, Randomized Clinical Trial
- Dehydrated human amnion/chorion membrane treatment of venous leg ulcers: correlation between 4-week and 24-week outcomes
- Fresh hypothermically stored amniotic allograft in the treatment of chronic nonhealing ulcers: a prospective case series
- Evaluation of lyophilized human amnion chorion membrane (LHACM) in the management of nonhealing diabetic foot ulcers
- Evaluation of dual layer amnion patch on the healing rate of chronic diabetic foot ulcers
- Efficacy of placental derived allografts and standard of care in the treatment of nonhealing diabetic foot ulcers using matched controls
- Evaluation of amnion chorion amnion placental allograft in the management of nonhealing diabetic foot ulcers and venous leg ulcers
- Full thickness placental membrane allograft for diabetic foot ulcers
- Evaluation of acellular human dermis graft on the healing rate of chronic diabetic foot ulcers
- A multicentre, prospective, randomized controlled modified platform trial evaluating PURION processed lyophilized human amnion chorion membrane and standard of care v. standard of care alone
- Efficacy of placental derived allografts and standard of care in the treatment of nonhealing diabetic foot ulcers using matched controls
- Evaluating the efficacy of placental-derived allograft in managing non-healing pressure ulcers
- Evaluation of lyophilized human amnion chorion membrane (LHACM) in the management of nonhealing diabetic foot ulcers
- Evaluation of single layer amniotic membrane in the management of nonhealing diabetic foot ulcers
The Journal of Chronic Wound Care Management and Research
As the official journal of House of Hyperbaric, The Journal of Chronic Wound Care Management and Research serves as a dedicated academic platform for peer-reviewed research in chronic wound prevention, assessment, treatment, and multidisciplinary care.
The journal welcomes contributions from researchers, clinicians, academics, key opinion leaders, and industry partners, including original research, systematic reviews, randomized controlled trials, case series, commentary, consensus documents, and educational resources. Its open-access model supports broader dissemination of clinically relevant findings that can inform evidence-based practice and improve wound healing outcomes.