Acute thermal burns can cause progressive tissue injury extending beyond the area initially damaged by heat. Edema, microvascular impairment, inflammation, and tissue hypoxia may contribute to conversion of potentially viable tissue into deeper burn injury.
Hyperbaric Oxygen Therapy (HBOT) is recognized by the Undersea & Hyperbaric Medical Society (UHMS) as an adjunctive treatment for acute thermal burn injury.
HBOT does not replace modern burn care. When used, it should be incorporated alongside airway management, fluid resuscitation, wound care, surgical excision, grafting, infection management, and other appropriate treatment.
Thermal burns result from exposure to heat sources such as:
Severe burns may involve multiple tissue zones.
The central area of injury may contain irreversibly damaged tissue, while surrounding tissue may remain viable but vulnerable to progressive ischemia and inflammation.
This surrounding tissue is sometimes described as the zone of stasis. Preserving this tissue is an important objective in early burn management because deterioration can increase burn depth and the amount of tissue requiring excision or grafting.
Patients with major burns may also have inhalation injury, carbon monoxide poisoning, trauma, shock, or other complications requiring immediate evaluation.
HBOT increases plasma oxygen concentration and tissue oxygen delivery while influencing several mechanisms involved in progressive burn injury.
Microvascular injury and edema can substantially reduce oxygen delivery to tissue surrounding a burn. HBOT increases dissolved plasma oxygen and may improve oxygen delivery to tissue that is hypoxic but still potentially viable.
Hyperbaric oxygen causes vasoconstriction while maintaining elevated tissue oxygen levels. This may reduce capillary leakage and edema, potentially improving microvascular conditions within injured tissue.
The zone surrounding the central burn injury may deteriorate during the first hours and days after injury. By improving tissue oxygenation and influencing inflammatory and ischemia-reperfusion pathways, HBOT may help preserve marginal tissue and reduce conversion from partial-thickness to deeper injury.
Adequate oxygen is important for: Leukocyte bacterial killing Fibroblast function Collagen synthesis Angiogenesis Epithelialization Tissue repair Improved tissue oxygenation may therefore support healing and resistance to infection during burn recovery.
Hyperbaric consultation may be considered for selected patients with significant acute thermal injury when HBOT can be provided without interfering with definitive burn care.
Potential situations include:
The decision should consider burn severity, total body surface area, associated injuries, clinical stability, transport requirements, and access to an appropriate hyperbaric facility.
The foundation of severe burn treatment remains specialized burn care.
Management may include:
HBOT should be coordinated with these interventions rather than interrupting or delaying them.
Patients with suspected smoke inhalation should also be evaluated for carbon monoxide and cyanide toxicity when appropriate.
Acute thermal burn injury is recognized by the Undersea & Hyperbaric Medical Society as an accepted indication for adjunctive HBOT.
The proposed benefits include improved tissue oxygenation, reduced edema, preservation of marginally viable tissue, modulation of inflammation, and support of wound healing.
Clinical evidence remains limited.
Systematic reviews have identified only a small number of randomized controlled trials, with concerns regarding study size and methodological quality. Other studies and clinical experience have reported potential reductions in wound progression, healing time, grafting requirements, or length of hospitalization.
Overall, the available evidence is not strong enough to support routine HBOT for every burn patient.
HBOT is therefore best considered an adjunct for carefully selected patients within an experienced burn and hyperbaric medicine program.
Although acute thermal burn injury is recognized by UHMS as an indication for HBOT, Medicare National Coverage Determination 20.29 specifically lists thermal skin burns as a noncovered condition.
Medicare also lists acute thermal and chemical pulmonary damage, including smoke inhalation with pulmonary insufficiency, as noncovered under this HBOT benefit.
This does not affect Medicare coverage for a separate covered diagnosis that may occur in a burn patient, such as qualifying carbon monoxide poisoning.
Commercial payer policies may differ and should be reviewed individually.
Consider hyperbaric medicine consultation for selected patients with:
HBOT should never delay airway management, resuscitation, surgical intervention, transfer to a burn center, or other established burn treatment.
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Undersea & Hyperbaric Medical Society. Hyperbaric Oxygen Therapy Indications: Acute Thermal Burn Injury.
Cianci P, Slade JB Jr, Sato RM, Faulkner J. Adjunctive hyperbaric oxygen therapy in the treatment of thermal burns. Undersea & Hyperbaric Medicine.
Villanueva E, Bennett MH, Wasiak J, Lehm JP. Hyperbaric oxygen therapy for thermal burns. Cochrane Database of Systematic Reviews.
Centers for Medicare & Medicaid Services. National Coverage Determination 20.29: Hyperbaric Oxygen Therapy.